Stephen Devoto, professor of neuroscience and behavior; Rosemary Doris, visiting assistant professor of biology; Ph.D. candidate Steffie Windner; and neuroscience and behavior major Chantal Ferguson ’13 are the co-authors of a paper that is the culmination of three years of research. The paper, titled “Tbx6, Mesp-b and Ripply1 Regulate the Onset of Skeletal Myogenesis in Zebrafish” is published in the March 2015 edition of Development, Vol. 142, No. 6, pages 1,159-1,168. The paper is a collaboration between Wesleyan, Kings College London and the National Institute for Medical Research (MRC).
Devoto highlights the importance of the paper:
The paper identifies three new regulators of muscle development, using research with genetically modified zebrafish. It shows that these three proteins form a network that regulate each other. These three proteins and the genes that encode them also regulate the most basic vertebrate features – the body segments that will form the vertebrae and ribs. Thus, the paper demonstrates a genetic linkage between segmentation and muscle development.
The paper’s abstract can be found here.